Ukrainian Journal of Chemotherapy.- 2003.- № 3-4.
Abstracts

Contents

Spreading and profile of drug resistance M. tuberculosis in patients of institute of phthisiology & pulmonology for 2000-2002 years
Yu.I. Feschenko, O.A. Zhurylo, A.I. Barbova, L.V. Veselovsky, P.S. Trofimova, S.V. Mironchenko, L.V. Spasenko
It is presented results of retrospective analysis of drug resistance of M. tuberculosis, obtained from a clinical stuff by inpatients of tuberculosis found on fixed treatment in ITP AMS since 2000 until 2002. It was established increasing of rate of drug resistance M. tuberculosis. It was revealed tendency of rate rising of multidrug resistant MBT among all drug resistant strains as well as resistant to 5-6 antituberculous drugs.
Key words: Mycobacterium tuberculosis, susceptible and resistance to drugs, multidrug resistance, poliresistance, monoresistance.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 3 - 6

Blood bacteriostatic activity of different combinations of moderate efficient antituberculous drugs
S.A. Cherenko, E. R. Tarasenko, O. A. Zhurylo, Zh. E. Vyalych
Blood bacteriostatic activity (BBA) was studied in 68 patients with tuberculosis after 2, 3, 6 and 12 hours after dose of moderate efficient antituberculosis drugs and their combinations in average therapeutic doses. It was established that moderate efficient antituberculosis drugs appear synergism to each other in bacteriostatic activity. It was determined that combined application of that drugs (2–5 medications) in one dose - provide higher level of blood bacteriostatic activity, which are retain more longer than after dosed only 1 drug. Blood bacteriostatic activity didn't increase and prolong period of high drug concentration in patient's blood with increasing of number drugs for one application in comparison with 2 drugs.
Key words: lung tuberculosis, blood bacteriostatic activity, moderate efficient antituberculosis drugs.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 7 - 10

Epidemiological situation regarding tberculosis in combination with HIV-infection AIDS in Ukraine
T.A. Alexandrina
Results of analysis of morbidity and mortality of tuberculosis in combination with HIV and AIDS in Ukraine during last 5 years showed lack of reliable data about frequency of combined disease due to divergence of official statistic and executive data, obtained from regional administrations of public health. Most of cases of combined disease are not detected in Ukraine because of poor organization of diagnostic process. Developed system of TB detection among patients with HIV/AIDS, which consists in prophylactic radio examination of asymptomatic patients with HIV/AIDS and detailed radio and clinical examination of symptomatic patients with pyrexia, which exists a long time and concordant activity of centers of prophylaxis and control AIDS and antituberculous dispansers, is efficient and allows to detect most of TB cases among population of HIV patients.
Key words: tuberculosis and AIDS, tuberculosis and HIV, morbidity of tuberculosis, morbidity of HIV, morbidity of AIDS.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 11 - 15

Efficacy of Tercef (ceftriaxone), manufactured by balkanpharma, in complex treatment of patients with surgery infection
O.A. Beliaeva
The results of the clinical study indicate high efficacy of Tercef (ceftriaxone), manufactured by Balkanpharma, in the treatment of the abdominal surgery infections in dosage 2 g daily during 10–16 days and in the treatment of erysipelatous inflammation and acute thrombophlebitis in dosage 1 g daily during 5–10 days. The positive result observed in the 86,1% of cases.
Key words: abdominal surgery infections, abdominal sepsis, erysipelatous inflammation, acute thrombophlebitis, Tercef (ceftriaxone).
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 17 - 20

Spectrum of community acquired pneumonia pathogens and treatment with taking into consideration theirs resistance
V.P. Melnik, D.S. Razborov, O.A. Sirosh
For treatment community acquired pneumonia must be use antibacterials that are effective against gram-positive and gram-negative flora, which may be determined after the first consultation, by means of sputum smear bacterioscopy. Cephalosporins (IV generation) or «respiratory» quinolone may be antibiotic of choice. Empirical therapy, after microbiological determination of pathogen, must be change to ethiologycal therapy with taking into consideration antibiogram.
Key words: community acquired pneumonia, microbes, resistance, antibacterial therapy.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 21 - 23

Efficacy of sequential therapy with ciprofloxacin in patients with nosocomial pneumonia, admitted to intensive care unit due to myocardial infarction
O.Ya. Dzyublik, O.O. Mukhin, K.M. Amosova, M.O. Moskvichev, R.E. Sukhin, A.V. Sablin, N.V. Melnichenko, Ya.Yu. Macheret
The results of the study indicated, that seqential regimen of antibacterial therapy with ciprofloxacin (400 mg intravenously twice a day during 3 days, and than 500 mg twice a day per os) was effective in patients with AMI, who developed nosocomial pneumonia after admitting in coronary care unit. As reported, 100% patients revealed clinical improvement.
Key words: nosocomial pneumonia, antibacterial therapy, ciprofloxacin, myocardial infarction.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 24 - 27

Ifluence of educational programs on the rate of hospital-aquired pneumonia morbidity in surgical departments
R.O. Bontsevych
The results of the investigation are shown in this article devoted to the influence of education of the surgery departments stuff on the rate of hospital-aquired pneumonia morbidity. The necessity of such education is high, because it influences on decreasing the rate of hospital-aquired pneumonia.
Key words: hospital-aquired infections, hospital-aquired pneumonia, educational programs.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 28 - 30

Efficacy of fosfomycin trometamol application in patients with acute and chronic uncomplicated cystitis
I.I. Lapchynska, A.Ye. Gromova
The results of conducted study evidenced, that monotherapy with fosfomycin trometamol (3 g once in acute cystitis and twice with intervals 24 hours in chronic cystitis per os) was highly effective in patients without concomitant diseases and complications.
Key words: acute and chronic cystitis, antibacterial therapy, fosfomycin trometamol, Monural.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 31 - 33

Combination gemcitabine/cysplatin for advanced non-small cell lung cancer (NSCLC)
V.D. Zakharychev, V. M. Sovenko
Here we present our experience of chemotherapy by gemcitabine plus cisplatin comparing with cisplatin plus etoposide for advanced NSCLC. 46 previously untreated with chemotherapy patients with NSCLC in III-IV stages, were divided to 2 groups: in the 1 group patients (n=22) received gemcitabine and cisplatin in combination, in the 2 group (n=24) cisplatin plus etoposide. Both groups were equable by basic prognostic features. Efficacy of treatment in the 1 group was for certain (p 0,05) more effective (63,6%) than in the 2 group (29,2%), scheme of treatment in the 1 group had more propitious profile of toxicity.
Key words: non-small cell lung cancer, chemotherapy, gemcitabine, cisplatin, etoposide.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 34 - 38

The toxicity of chemoradiotherapy with different chemotherapy regimens for locally advanced breast cancer management
O.S. Bondaruk, V.S. Ivankova, L.M. Baranovskaya, T.V. Udatova, M.A. Bagiryan
The toxicity and safety profile of different chemotherapy regimens in combination with curative radiotherapy were studied during the management of locally advanced breast cancer.
Key words: locally advanced breast cancer, chemoradiotherapy, treatment's toxicity.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 39 - 43

Efficacy of cisplatin and 5-fluorouracil-contained chemoradiotherapy for locally advanced cervical cancer treatment
G.O. Kurilo, V.S. Ivankova, O.S. Bondarouk
69 women's with squamous cell cervical carcinoma on III stage, were treated in the radiotherapy department of Oncology Institute AMS of Ukraine by chemoradiotherapy (CRT) and radiotherapy, or radiotherapy (RT) alone. The RT regimen were the similar at both groups — external RT to a total dose 30 Gy/15 fractions/3 weeks (opposite fields techniques) following the external radiotherapy (ERT) up to the total dose 50–55 Gy and brachytherapy boost (60Co HDR-sources) to a dose 40–50 Gy/4-5 fractions/4–5 weeks. ERT was carried out by using 60Co-units or linear accelerator «Mevatron». The women, who received 5-fluoruoracil infusions during 5 days before RT (350 mg/m2/day), than first three sessions were carried out on the background of cysplatinum to a total dose of 60 mg/m2. Analysis of immediate results demonstrated increasing of overall (complete and partial) response in 1-st group in comparison with 2-nd. These data showed good patient tolerance and encouraging response to RT combined with chemotherapy.
Key words: locally advanced cervical carcinoma, chemoradiotherapy, cisplatinum, 5-fluorouracil.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 44 - 47

Midecamycin in treatment of respiratory diseases in children
E.V. Sereda, L.K.Katosova
The article is dedicated to midecamycin, a macrolide-group antibiotic. The authors present herein a detailed description of the drug’s pharmacokinetics, the spectrum of activity against causative agents of inflammatory diseases of the respiratory organs in children, also reporting own findings concerning the efficacy (both clinical, and bacteriological) of administration of midecamycin and midecamycin acetate in 76 children: those suffering from acute pneumonia (21 children) and 55 patients with chronic and relapsing respiratory diseases.
Key words: macrolides, midecamycin, midecamycin acetate, respiratory infections, children
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 48 - 52

Moxifloxacin: the Present and the Future in the Sequential Therapy
L.S. Stratchounski, A.V. Veselov, V.A. Kretchikov
Moxifloxacin is a new broad spectrum 8-methoxiquinolon with high activity against both Gram(+) and Gram(–) microorganisms as well as against anaerobes and intracellular pathogens. It is also active against microorganisms that are resistant to other classes of antimicrobials, including penicillin- and macrolid-resistant pneumococci and b-lactamaseproducing Haemophilus influenzae. An excellent activity against the above mentioned pathogens and good pharmacokinetic profile allows to use moxifloxacin for monotherapy of respiratory tract infections. High clinical efficacy and safety of moxifloxacin has been demonstrated in treatment with sequential therapy of community acquired pneumonia in the controlled clinical trials. The literature review of clinical trials on sequential (IV/PO) moxifloxacin therapy in patients with communityacquired pneumonia is presented in the article. An attempt to analyse the perspectives of further moxifloxacin usage is made.
Key words: moxifloxacin, fluoroquinolones, pneumonia, sequential therapy.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 53 - 64

Paclitaxel in the treatment of women with genital cancer
A.B. Vinnytska
Summary. Adducing materials on greatly efficacy of paclitaxel using on first and second line of chemotherapy in treatment of women with ovarian carcinoma on late stages and other localization of genital cancer — cervical carcinoma, endometrial carcinoma.
Key words: women with genital cancer, ovarian carcinoma, cervical carcinoma, endometrial carcinoma, chemotherapy, paclitaxel, Mitotax.
Ukr. J. Chemotherapy.- 2003.- N 3-4.- P. 65 - 69

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