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DISCOVERY OF STREPTOMYCIN - HISTORICAL MARK IN CHEMOTHERAPY OF TUBERCULOSIS (by 115 anniversary from birthday of Selman Abraham Waksman)
B.M. Pukhlyk, V.A. Kucher
Stages of development of chemotherapy of tuberculosis are submitted in this article. The vital importance of streptomycin as first antibiotic working against Mycobacterium tuberculosis is described. Brief Waksman's biography is given and it is told about his historical role in creation of streptomycin.
Key words: S.A. Waksman, tuberculosis, chemotherapy, Mycobacterium tuberculosis, streptomycin.
Pukhlyk B.M., Kucher V.A. DISCOVERY OF STREPTOMYCIN - HISTORICAL MARK IN CHEMOTHERAPY OF TUBERCULOSIS (by 115 anniversary from birthday of Selman Abraham Waksman) // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 3 - 9

STRATEGY OF PROPHYLAXIS, DIAGNOSTICS AND TREATMENT PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS
Yu. I. Feschenko, V. M. Petrenko, S.O. Cherenko, G.I. Barbova
The article contains the complex of measures on organization antituberculosis care for adult with multidrug resistant lung tuberculosis and provides control on all steps of tuberculosis prophylaxis, diagnostics and treatment.
Key words: multidrug resistant tuberculosis, prophylaxis, diagnostics, treatment.
STRATEGY OF PROPHYLAXIS, DIAGNOSTICS AND TREATMENT PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS / Yu. I. Feschenko, V. M. Petrenko, S.O. Cherenko, G.I. Barbova // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 10 - 20

DIAGNOSTICS AND TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN INFECTIVE-DEPENDING EXACERBATIONS
Yu.M. Mostoviy, V.O. Galinska
Represented materials about diagnostics and treatment of chronic obstructive pulmonary disease in infective-depending exacerbations. Spectrum analysis of possible pathogens, role of pathogens in bronchoobstructive syndrome and approaches to choice of antibacterial therapy were realized. Registered preferences of clarithromycin (Fromilid) as a medication of choice for treatment of bronchial asthma and chronic obstructive bronchitis in infective-depending exacerbations, since clarithromycin have high antimicrobial activity in attitude to possible pathogens, since clarithromycin have some bronchodilatating effects, that is not inherent to other antibiotics.
Key words: chronic obstructive pulmonary disease in infective-depending exacerbations, antibacterial therapy, clarithromycin, Fromilid.
Mostoviy Yu.M., Galinska V.O. DIAGNOSTICS AND TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN INFECTIVE-DEPENDING EXACERBATIONS // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 21 - 26

ETHIOLOGICAL FACTORS OF CHRONIC OBSTRUCTIVE BRONCHITIS in EXACERBATION
V.P. Melnyk, O.V. Panasuk, O.A. Sirosh, D.S. Razborov
Patients with an infectious exacerbation of a chronic obstructive bronchitis have been investigated. The spectrum of microorganisms at these patients is determined and resistency patogenes to the basic groups of antibiotics is investigated.
Key words: chronic obstructive bronchitis, infectious exacerbation, spectrum of microorganisms, resistance.
ETHIOLOGICAL FACTORS OF CHRONIC OBSTRUCTIVE BRONCHITIS in EXACERBATION / V.P. Melnyk, O.V. Panasuk, O.A. Sirosh, D.S. Razborov // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 27 - 28

EFFICACY OF TREATMENT IN PATIENTS WITH FIRST DIAGNOSED DESTRUTIVE LUNG TUBERCULOSIS WITH BACTERIAL ABJECTION DEPENDING ON QUANTITY OF CAVERNAES
N.A. Litvinenko
In this article cite data about efficacy of treatment in patients from two groups with first diagnosed destructive lung tuberculosis with bacterial abjection to quantity of cavernaes: with one cavity (first group) or with two and more cavitas (second group). Intoxication had vanished after 1,1±0,1 months in patients from first group and after 1,7±0,2 months in patients from second group; bacterial abjection aborted in 100 and 90,0±3,3% of consumptives, closed up cavitas in 90,8±3,4% and in 78,8±4,6% of patients from first and second groups accordingly (p<0,05).
Key words: regimens of antituberculous chemotherapy, abort of bacterial abjection, tuberculosis intoxication, quantity of cavernaes in lung, closed up cavitas.
Litvinenko N.A. EFFICACY OF TREATMENT IN PATIENTS WITH FIRST DIAGNOSED DESTRUTIVE LUNG TUBERCULOSIS WITH BACTERIAL ABJECTION DEPENDING ON QUANTITY OF CAVERNAES // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 29 - 34

PECULIAR PROPERTIES OF CLINICAL COURSE AND TREATMENT OF VARIOUS FORMS UROGENITAL CANDIDIASIS
S.S. Leush, G.F. Roshina, O.F. Poltavtceva, I.V. Macidonska, L.S. Tkach
The results of conducted investigations is testify to effective, quick and economically advantage results of treatment vaginal candidiasis and for prophylaxis generalized candidiasis by FUNGOLON against a background of using antibiotics.
Key words: urogenital candidiasis, vaginal candidiasis, generalized candidiasis, recurrence course of candidiasis, FUNGOLON (fluconazol).
PECULIAR PROPERTIES OF CLINICAL COURSE AND TREATMENT OF VARIOUS FORMS UROGENITAL CANDIDIASIS / Leush S.S., Roshina G.F., Poltavtceva O.F., Macidonska I.V. et al. // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 35 - 38

EFFICACY OF CIPROFLOXACIN IN COMPLEX TREATMENT OF ADULT PATIENTS WITH SEVERE AND MIDDLE HEAVINESS SALMONELLOSIS
O.V. Melnyk
Efficacy of ciprofloxacin in complex treatment of patients with severe and middle heaviness salmonellosis, in particular with gastrointestinal-shaped, was estimated. We established that using of ciproflocsacin accelerate terms of clinical recovery, reduce frequency of bacterial abjection, well tolerate by patients, prevent evolution of complicates and shorten duration of illness. Sensitiveness of diagnosed specimens of salmonella to broad-spectrum antibiotics was specified. More active, with respect to pathogen, are preparations from the group of fluoroquinolons, in particular ciprofloxacin.
Key words: salmonellosis, resistance, ciprofloxacin, furazolidon, efficacy.
Melnyk O.V. EFFICACY OF CIPROFLOXACIN IN COMPLEX TREATMENT OF ADULT PATIENTS WITH SEVERE AND MIDDLE HEAVINESS SALMONELLOSIS // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 39 - 42

EFFICACY OF CHEMORADIOTHERAPY WITH ANTHRACYCLINE-CONTAINED CHEMOTHERAPY UNDER LOCALLY SPREAD BREAST CANCER
O.S. Bondaruk
Usage of the scheme with applying of anthracyclines («modified» CAF: doxorubicin hydrochloridi - 30 mg/m², cyclophosphamide - 700 mg/m², fluorouracilum - 500 – 600 mg/m² intravenously in 1st and 8th days) in union with radiotherapy (total dose 60 – 64 Gy on breast area and 40 – 44 Gy on lymph outflow ways) and hormonotherapy is effective and safe for locally advanced breast cancer treatment. Thanks to these combination significantly increases the level of disease-free survival in comparison with radiotherapy and hormonal therapy along during 2-years follow-up.
Key words: locally advanced breast cancer, chemoradiotherapy, treatment's toxicity, efficacy of treatment.
Bondaruk O.S. EFFICACY OF CHEMORADIOTHERAPY WITH ANTHRACYCLINE-CONTAINED CHEMOTHERAPY UNDER LOCALLY SPREAD BREAST CANCER // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 43 - 47

USE OF AN ANTICANCER AUTOVACCINE FOR COMPLEX TREATMENT OF THE BREAST CANCER PATIENTS
G.P. Potebnja, S.Yu. Sklyar, G.D. Bendjug, V.V. Zaychuk, G.S. Lisovenko, L.N. Kokhanovskaja, L.I. Rusanova
The data of using of an anticancer autovaccine for complex treatment of the breast cancer patients are submitted. It were no complications, that could essentially influence on common state of patients after injection of anticancer autovaccine during the postoperative period. It was demonstrated, that vaccinotherapy along with the basic methods of anticancer therapy promoted decrease of the blocking factors in the serum; reinforced lymphocytes blast transformation reactions not only at presence FGA, but also autovaccine; enhanced reaction of delayed type hypersensitivity at statement of dermal assay with an autovaccine, that testifies to increasing functional activity of Т-lymphocytes under influence of a vaccinotherapy.
Key words: breast cancer, complex treatment, anticancer autovaccine, immunological parameters.
USE OF AN ANTICANCER AUTOVACCINE FOR COMPLEX TREATMENT OF THE BREAST CANCER PATIENTS / G.P. Potebnja, S.Yu. Sklyar, G.D. Bendjug et al. // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 48 - 52

PECULARITIES OF ANTIBIOTICOTHERAPY IN PATIENTS WITH CHRONIC RENAL FAILURE AND UNDER RENAL SUBSTITUTIVE THERAPY
M.O. Kolesnyk, I.I. Lapchynska, Kh.V. Senyuk
Described changes of drug properties (volume of distribution, bounding up with plasma proteins etc.) under renal substitutive therapy. Represented notions of dyalisability of drugs and the factors that influence on it were elucidated. The methods of evaluation of dialysability of drugs and ways of calculation of antibiotic doses under renal replacement therapy, described doses of antimicrobial drugs depending on level of chronic renal failure.
Key words: renal replacement therapy, antibiotics, volume of distribution, bounding up with plasma proteins, dialysability.
Kolesnyk M.O., Lapchynska I.I., Senyuk Kh.V. PECULARITIES OF ANTIBIOTICOTHERAPY IN PATIENTS WITH CHRONIC RENAL FAILURE AND UNDER RENAL SUBSTITUTIVE THERAPY // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 53 - 59

4-TH WORLD CONGRESS ON TUBERCULOSIS: SUMMARY OF ACHIEVMENTS AND PERSPECTIVES IN FUTURE
S.O. Cherenko
It was reviewed the most imortant problematic presentations and summary of 4-th World congress on tuberculosis, that held 3–5 of June 2002 in Washington. The presentations are about tuberculosis epidemic in the world, global situation of drug multiresistant tuberculosis, problems of diagnostics of tuberculosis, developments of new antituberculosis frugs and vaccines.
Key words: DOTS-strategy, tuberculosis control, antituberculosis drugs.
Cherenko S.O. 4-TH WORLD CONGRESS ON TUBERCULOSIS: SUMMARY OF ACHIEVMENTS AND PERSPECTIVES IN FUTURE // Ukr. J. Chemotherapy.- 2003.- N 2.- P. 60 - 64

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